Structure-Guided Biochemical Analysis of Quorum Signal Synthase Specificities
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چکیده
منابع مشابه
Corrigendum: Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase
In the Results section under subheading 'In silico evaluation of the interaction between TZD and LasI. ' " A LIGPLOT view of the interaction schema between LasI and TZD-C8 in the three highest energy binding states showed direct hydrogen bonds between the ligand and Arg30 and Ile107 (Supplementary Data Figure S4A) ". should read: " A LIGPLOT view of the interaction schema between LasI and TZD-C...
متن کاملMechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen responsible for many human infections. LasI is an acyl-homoserine lactone synthase that produces a quorum-sensing (QS) signal that positively regulates numerous P. aeruginosa virulence determinants. The inhibition of the LasI protein is therefore an attractive drug target. In this study, a novel in silico to in vitro complementat...
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The human pathogen Pseudomonas aeruginosa uses the pqs quorum sensing system to coordinate the production of its broad spectrum of virulence factors to facilitate colonization and infection of its host. Hereby, the enzyme PqsD is a virulence related quorum sensing signal synthase that catalyzes the central step in the biosynthesis of the Pseudomonas quinolone signals HHQ and PQS. We developed a...
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Quorum-quenching (QQ) are natural or engineered processes disrupting the quorum-sensing (QS) signalling which controls virulence and persistence (e.g. biofilm) in numerous bacteria. QQ involves different enzymes including lactonases, amidases, oxidases and reductases which degrade the QS molecules such as N-acylhomoserine lactones (NAHL). Rhodococcus erythropolis known to efficiently degrade NA...
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Some bacteria produce and perceive quorum-sensing (QS) signals that coordinate several behaviours, including the costly processes that are exoenzyme production and plasmid transfer. In the case of plasmid transfer, the emergence of QS signal-altered invaders and their policing are poorly documented. In Agrobacterium tumefaciens, the virulence Ti-plasmid encodes both synthesis and sensing of QS-...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2020
ISSN: 1554-8929,1554-8937
DOI: 10.1021/acschembio.0c00142